The integration analysis found significantly dysregulated miRNA–gene pairs in ASD. The integration of mRNA and miRNA sequencing profiles by miRWalk2.0 identified correlated changes in miRNAs and their targets’ expression. The functional enrichment analysis showed pathways involved in ASD control proliferation of neuronal cells, cell death of immune cells, epilepsy or neurodevelopmental disorders, WNT and PTEN signaling, apoptosis, and cancer. The RT-qPCR analysis confirmed the sequencing results for randomly selected candidates: AUTS2, FMR1, PTEN, hsa-miR-15a-5p, hsa-miR-92a-3p, and hsa-miR-125b-5p. The top upregulated genes were GABRA4, AUTS2, and IL27, and the top upregulated miRNAs were hsa-miR-6813-3p, hsa-miR-221-5p, and hsa-miR-21-5p. The sequencing analysis identified 1700 genes and 102 miRNAs differentially expressed between the ASD and control LCLs ( p ≤ 0.05). Herein, we studied lymphoblastoid cell lines (LCLs) from children diagnosed with autistic disorder ( n = 10) and controls ( n = 7) using RNA and miRNA sequencing profiles. Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with mutations in hundreds of genes contributing to its risk.
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